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Numerous disease states, such as diabetes, cardiovascular disease, and cancer, are characterized by aberrant mTOR signaling

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27,28 Methadone maintenance is used to relieve narcotic craving, suppress the abstinence syndrome, and block the euphoric effects associated with opioids

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Nonetheless, the deletion of Nrf2 prevented the increased expression of NRF2 protein and the induction of NRF2 targets upon Gclc deletion in liver tissue (Fig