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When p62 is knocked down via RNA interference, the expression of NQO1, HO-1 and ferritin heavy chain is decreased, exacerbating erastin-induced ferroptosis (45,46)

Summary IGF-1 LR3 solves a specific problem in IGF research: the short half-life of native IGF-1 due to IGFBP sequestration

In those human studies, the results were mixed, with some showing that oxidative damage was reduced with long term supplementation [15, 21] and another showing no reduction in oxidative damage [16]

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While FOXO4 can influence mitochondrial function indirectly through its regulatory effects on cellular processes, it does not directly target mitochondria like the other mitochondria-targeted peptides listed above