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To meet the increased demand for energy and substance synthesis, tumor cells change their flux by adjusting various metabolic pathways and targeting metabolic pathways has gradually become a focus of tumor therapy research (61)

Although multiple approaches to regenerative therapeutics have been under investigation for several years, we are still missing a comprehensive methodology that combines cellular gene expression, molecular signaling, and the ECM structure to construct native tissue-like replacements

In the second part of the study, we compared the effects of long-term (four-day) exposure to DMSO on yeast cells with varying antioxidant system efficiency (wild type cells and sod1 and sod2 mutants) and with varying energy metabolism (aerobic, mixed respiratory-fermentative and fully fermentative metabolism) to identify cellular targets which are particularly sensitive to this xenobiotic

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D.GeddieH.OlivierL.CairnsM.TruterN.BeselaarL.et al (2020)