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Acknowledgments Editorial assistance, including figure formatting and editorial review, was provided, under the direction of the authors, by Patricia Johansen, Ph.D., Synchrony Medical Communications, LLC, West Chester, PA, USA

An -hydroxy acid sometimes produced at high levels by cancer cells, which structurally resembles -ketoglutarate and so inhibits -ketoglutarate-dependent enzymes such as the Jumonji-family histone demethylases

Nanomedicine 19, 541569

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice