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NaBPC157 (administered either in the ng or g/kg range, i.p.) significantly reduced the reactions in the writhing (inflammatory and non-inflammatory, prostaglandin-dependent and independent) and tail pinching tests

In this investigation, we initially identified oridonin as a direct covalent inhibitor of GSH, setting it apart from other drugs that disrupt ROS by targeting proteins both upstream and downstream of GSH

They act as antioxidants to combat oxidative stress

Additionally, those with medical conditions, such as Diabetes, COPD and neurodegenerative diseases can experience low glutathione levels

Kadowaki M, Yamada H, Sato K, Shigemi H, Umeda Y, Morikawa M, et al

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