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Updated 2/11/2020

Clin Chem Lab Med (2012) 50:135966

and third, it prevents damage from oxidative stress, directly by reducing mitochondrial respiration and therefore the generation of reactive oxygen species (ROS), and indirectly by the production of nicotinamide adenine reduced dinucleotide phosphate (NADPH) through the pentose pathway (PPP), which maintains glutathione (GSH) in a reduced state, the main non-protein thiol that acts as an intracellular redox regulator (Marcucci and Cristiano, 2021)

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It is used to manage alcoholic fatty liver (disease that occurs due to heavy alcohol use), liver fibrosis/cirrhosis (scarring of liver due to excessive consumption of alcohol), and hepatitis (inflammation of liver) in affected individuals

McGraw-Hill, New York Benyo Z, Gille A, Bennett CL, Clausen BE, Offermanns S (2006) Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells