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In particular, activated Th1 T cells produce IFN-, which can activate monocytes/macrophages, which in return may activate T and B cells via antigen presentation, whilst B cell-derived antibodies are able to activate monocytes/macrophages expressing the FcRI receptor

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Consequently, potential users should exercise caution and consult healthcare professionals regarding its use, especially because of cancer risks associated with its angiogenic effects 4