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Similarly, mouse immature DCs were genetically engineered to secrete exosomes expressing the Lamp2 protein fused with the iRGD peptide (CRGDR/KGPDC) and demonstrated highly efficient targeted drug delivery to v integrin-positive breast cancer cells, consequently inhibiting tumor growth 36

This occurred as it had been noted in BuddChiari syndrome BPC 157 therapy, with either intraperitoneal or per-oral application [27], indicative for the syndrome of the occluded superior sagittal sinus

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Being approved by FDA in 2012, Ivacaftor is the first commercially available treatment to target the basic defects in CF (Pettit, 2012)

The animal was placed on a stereotaxic frame to perform a left craniotomy