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The intestinal epithelium barrier provides a defence against the entry of harmful substances, such as pathogens and toxins, whilst simultaneously permitting sufficient absorption of nutrients, electrolytes, and water from the gastrointestinal lumen [14]

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Rare variants in known and novel candidate genes predisposing to statin-associated myopathy

Recent evidence suggests systemic therapy, either targeted agents or immunotherapy, can be effective in combating BrMs, especially those originating from well-characterized primary tumors ( The establishment of metastatic cancer encompasses entering the central nervous system (CNS) from the blood and crossing the BBB ( Recent accumulating evidence suggests that B cells play a multifaceted and relatively underexplored role in shaping the BrM tumor microenvironment (TME)