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B12 may occasionally cause mild digestive upset, while excessive D3 intake over extended periods could lead to calcium buildup, though this is rare with normal dosing

Importantly, Polireddy et al

Vitamin D does play a very important role in the prevention of rickets in children, and also in the development of osteomalacia in adults

Ferreira LM, Hebrant A, Dumont JE (2012): Metabolic reprogramming of the tumor

Targeted over-expression of glutamate transporter 1 (GLT-1) reduces ischemic brain injury in a rat model of stroke

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