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However, CD-839 does not exert significant antitumor effects on pancreatic cancer cells, suggesting that monotherapy led to metabolic adaptation in cancer cells [185]

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Ipamorelin's durable contribution, as recognized in the primary literature, is its demonstration that GHS-R1a agonism could be pharmacologically dissociated from co-stimulation of the hypothalamic-pituitary-adrenal axis, evidence of signal diversity at the receptor that informed subsequent compound design