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[54] found that folic acid (100 mg/L) improved oocyte ovulation rates in NaF-treated C57BL/6 mice (60 mg/L, for 20 days) through Sirt1/Sod2-dependent mechanisms [54]

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To address these issues, future research should focus on three key areas: First, analyzing the dynamic characteristics of uric acid signaling across different populations, ages, and metabolic states to clarify its physiological and pathological thresholds through multi-omics and longitudinal cohort studies