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Pain medicine (Malden, Mass) .Mar 2 2022;23(3):499-514

GeilerJMichaelisMNaczkPLeutzALangerKDoerrHet al

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2015 May;40(6):1405-16

Unfortunately, these anti-IGF-1R agents have very limited efficacy in clinical trials, 7,8,9 suggesting the existence of a mechanism to antagonize the IGF-1R inhibition in cancer cells