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Generally, HO-1 levels remain low across diverse tissues except for the spleen, but diverse stimuli (like hydrogen peroxide, UV radiation, endotoxins, and hypoxia) can cause a strong inducible response for shielding cells from damaging oxidative and inflammatory agents [34]

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In this context, phytochemicals, with their wide availability, structural diversity, favorable safety profiles, and capacity to regulate multiple biological targets, have emerged as valuable resources for novel drug development ( Here we summarize the critical role of microglia-mediated neuroinflammation in morphine tolerance, with a particular focus on summarizing recent research on phytochemicals that modulate microglial function to alleviate morphine tolerance