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Normally vitamin D is produced in the skin by sunlight, taken through supplements and found in oily fish, such as sardines, herring, salmon and mackerel, after which it is converted by several steps in the body into the active form, which provides the health benefits

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Kathuria A, Lopez-Lengowski K, Vater M, McPhie D, Cohen BM, Karmacharya R, et al

Bimodal Cellular Opioid Response: Opioids induce both inhibitory Gi-coupled and stimulatory Gs-coupled receptor responses