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These findings suggest that co-targeting the AR and PI3K/AKT pathways may overcome resistance mechanisms and offer a promising therapeutic strategy for advanced, PTEN-deficient prostate cancer [84]

[PubMed: 20020370] 165

Holthoff et al., 2005

GPS has been shown to significantly enhance the migration and proliferation of fibroblasts, which are essential for collagen synthesis and tissue repair

When necessary and possible, model fitting parameters, and potential outlier publications were explored using different influence measures and plots (e.g., leave-one-out analysis for changes in fitted values, Bujat diagnostics values and plots) as recommended by Harrer et al

In KEAP1-deficient lung cancer cells, the upregulated Nrf2 translocates to the nucleus and binds to antioxidant response elements, activating genes critical for redox homeostasis