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Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: Relationship between homocysteine levels and hyperinsulinemia

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In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, and 2aa

Metformin interferes with the absorption of vitamin B12 in the small intestine, which over time may lead to a deficiencyespecially if the drug is taken for several years

However, as with any medical intervention, its crucial for individuals to consult with their healthcare providers before initiating B12 supplementation

In summary, use the injections for as long as they are providing a clear benefit and need