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Mitochondrial dysfunction A series of five main protein complexes integrated into the inner mitochondrial membrane form the mitochondrial electron transport chain (ETC), which utilizes electron-transfer reactions responsible for ATP generation via oxidative phosphorylation (Nolfi-Donegan et al

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3 Thyroidbrain axis pathophysiology and neurological manifestations The major mechanistic routes linking thyroid dysfunction to neuropsychiatric manifestations are summarized in Figure 2, highlighting disrupted hormone transport/activation in the brain, neurotransmitter imbalance, oxidative stressneuroinflammation, and bloodbrain barrier vulnerability

PubMed+1 If there isnt enough water in your body, the discs function is impairedthis can contribute to pain, stiffness, swelling and longerterm problems