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[28] However, research does suggest that B12 deficiency may contribute to increased systemic inflammation

Funding This work was supported by the Science and Engineering Research Board (SERB) (CRG/2020/000865), India, Department of Biotechnology (BT/PR62235/MRNAR/169/15/2025), and the Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers (MoCF), National Institute of Pharmaceutical Education and Research (NIPER), S.A.S

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This process thereby downregulates the NF-B pathway, augments Treg differentiation, and suppresses Th17 expansion and inflammatory cytokine release (215, 216)