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For instance, reversed were increased number of inflammatory cells (38, 44-46) and the rise of leukotriene B4 (LTB4), thromboxane B2 (TXB2), and myeloperoxidase (MPO) in the serum and inflamed tissues (47-49)

1,2,6 Because nonantimicrobial sulfonamides lack an arylamine group, they do not produce similar metabolites, which is the reason they do not cross-react in patients who have had nonIgE-mediated reactions to antimicrobial sulfonamides