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William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition

Riboflavin (B2)

Microcytic anaemia occurs when red blood cells are smaller than normal, while megaloblastic anaemia involves abnormally large red blood cells and is more commonly associated with vitamin B12 deficiency

Many people initially experience only overwhelming fatigue: the kind where you go to bed exhausted and wake up just as tired

B12 is safe for most, but interactions should be reviewed