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Historically, all these parameters were provided by oral mucosa biopsy

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Drug-metabolizing enzymes and efflux transporters in nasal epithelium: influence on the bioavailability of intranasally administered drugs

Methods: Mouse models of advanced liver diseases were established by exposure to carbon tetrachloride (CCl 4 ) for 12 weeks, or high-fat, methionine-choline deficient diet (HFMCDD) for 16-20 weeks, mirroring human cHCV or MASLD pathology, respectively

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