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JAMA 312:26682675

117,118 In the spinal cord of SOD1 G37R mutant mice, more than 50% of the mutant SOD1 protein is not fully Cu-bound, and treatment with a Cu-containing compound significantly decreased the levels of metal-deficient SOD1 and increased the pool of fully Cu-bound SOD1

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The development of enzyme-inhibiting peptides requires careful consideration of selectivity and duration of action

By weeks six through twelve, structural improvements become apparent, tissue becomes stronger, and range of motion improves

Copper accumulation also becomes a theoretical concern at extreme doses, though practical protocols stay well below problematic thresholds