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It is the most widely studied of the three, with a large body of preclinical literature on tendons, ligaments, and gut tissue

FOXO6, as the most evolutionarily divergent member of this group, exhibits tissue-specific expression, particularly in liver, muscle, and neural tissues, and its effects on insulin signaling significantly differ from the other isoforms

A 2023 safety trial (n=200) confirmed no hepatotoxicity or allergy beyond 1% (Babu et al., 2023)

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