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Following an initial event of RCD, DAMPs accumulation can trigger tissue inflammation which can further promote RCD to form a self-amplified circuit of necro-inflammatory loop that leads to exaggerated cell death and inflammation, eventually resulting in tissue damage and organ dysfunction [48, 49]

AMPK negatively regulates RANKL-induced osteoclast differentiation by controlling oxidative stress

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(PubMed) Cete Y, Dora B, Ertan C, Ozdemir C, Oktay C

J.JarockiV

Arginine-modifying enzymes in pulmonary fibrosis Beyond its metabolic roles, arginine is subject to post-translational modifications, such as methylation and citrullination, which significantly impact pulmonary fibrosis