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The risk of severe GI events is increased by the presence of the following factors: history of peptic ulcer disease or GI bleed, smoking, alcohol usage, concomitant usage of anticoagulants, or oral corticosteroids, older age, and poor general health status

Some of the modulated genes encode for the antioxidant enzymes superoxide dismutase, glutathione peroxidase, glutathione reductase, hemeoxygenase type 1 (HO-1), peroxiredoxin, thioredoxin reductase, thioredoxin, and metallothionein

PUFA-PLs are susceptible to lipid peroxidation induced by arachidonic acid (A)LOXs, which eventually results in the loss of the lipid bilayer and impairs cell membrane function, thus increasing ferroptosis (49)

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