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In addition, hypozincemia in obese individuals is negatively associated with anthropometric parameters such as body mass index (BMI) and waist circumference, as well as with biochemical parameters such as fasting blood glucose, insulin and leptin (88, 96, 98, 103, 104)

For instance, identifying loss-of-function mutations in the IL-36Ra gene has led to developing IL-36 inhibitors for patients with GPP (Johnston et al

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In each case, the secretin protein was detected, supporting the interpretation that the cross-reacting bands represent proteolytically digested secretin

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