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Similar rates of severe hypersensitivity reactions were observed in ZEPBOUND clinical trials for weight reduction and in ZEPBOUND trials for OSA

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(2014, Nature Medicine) established NNMT as a major regulator of metabolic rate in white adipose tissue, showing that NNMT knockdown in mice produced a lean phenotype with elevated energy expenditure providing the foundational rationale for NNMT inhibition as a metabolic research target

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