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Genetic abnormalities in any of these three components lead to a severe deficiency of creatine within the brain parenchyma, with the diagnostic hallmark of the disease being an almost absent creatine peak on 1 H NMR spectroscopy

Clinical outcomes The frequencies of primary outcomes, including fever, cough, and death are listed in Table 3

PPAR- [35, 36] and C/EBP- [37] are core transcription factors involved in adipocyte differentiation, and positive feedback occurs between them to induce differentiation, cloning and proliferation of adipocytes [38]

In concordance with the findings from in vitro migration and invasion assays, in vivo metastasis assay in nude mice also showed that overexpression of CRAT significantly increased the number of metastasis nodules formed in the lungs