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Sickle cell disease is caused by an inherited mutation in the globin gene that creates hemoglobin S, an abnormal form of hemoglobin which is prone to polymerization with deoxygenation resulting in sickling of red blood cells, hemolytic anemia, vascular occlusion of small vessels causing ischemic tissue and organ injury and recurrent painful crises

However, regular exercise training (i.e., non-extreme muscle damaging exercise) upregulates cellular antioxidant systems and diminishes oxidative stress, promoting functional performance and supporting healthy ageing [10]

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