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It simply means the central nervous system has adjusted its response to the stimulus

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doi: 10.3389/fcimb.2015.00036 41 MoreraDRoherNRibasLBalaschJCDoateCCallolAet al

Safety Profile of Conjugated Linoleic Acid in a 12-Month Trial in Obese Humans. Food and Chemical Toxicology 42 (10): 1701-09

CaporgnoMPBckerLMssnerCStirnemannEHaberkornIAdelmannHet al

In addition to inducing autophagic flux, spermidine reduces oxidative stress-related damage in aging models by inhibiting excessive reactive oxygen species (ROS) production and preventing necrotic cell death (227)