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Smithies has used the analogy of removing a steering wheel from a car: without it you soon find out why it has a steering wheel

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These Phase II results suggest that in prostate cancer patients who have preexisting cardiovascular disease, selecting the androgen deprivation therapy modality may differentially affect cardiac outcome 49

the concentration of the lipid component selected to reduce aggregation is about 1 to 15% (by mole percent of lipids)