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If a deficiency is detected, your doctor may recommend vitamin B12 injections, which are often more effective than oral supplements due to metformins impact on stomach absorption

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Dehydration and blood sugar fluctuations are the usual culprits

Further, those with higher B12 levels and taking high dose vitamins had better outcomes with stroke, death, and heart events compared to those with lower B12 levels and taking low dose vitamins (3)