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(2024), the comparatively high genetic variation in the Levantine Sea (Locci et al., 2024) may result from a combination of regional environmental and demographic factors

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Its deficiency in the human diet results in disturbances in many important biochemical and metabolic processes, such as an impaired glucose metabolism, disrupted bioenergetic processes, mitochondrial dysfunction, lactic acidosis (the consequence of pyruvate dehydrogenase [PDH] dysfunction in mitochondria), insufficient DNA synthesis due to low transketolase activity and ribose-5-phosphate synthesis in the pentose phosphate pathway and impaired neurotransmitter synthesis

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