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PMID: 19737957

It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint

doi: 10.1111/bpa.12426 208 LoisCGonzalezIIzquierdo-GarciaDZurcherNRWilkensPLoggiaMLet al

10.1136/postgradmedj-2020-139065 181

Copper deficiency and oxidative stress Copper deficiency has also been suggested to contribute to the development and progression of atherosclerosis via oxidative stress

In cases where the MIE is unknown or undefined, the earliest known KE in the chain (i.e., furthest upstream) should be used in lieu of the MIE and it should be made clear that the stated event is a KE and not the MIE