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Plotting was carried out using the ggplot2 library whereas filtering of proteome data was facilitated by the dplyr library both included in the tidyverse package [83]

b , The alternation of surface mainly derived from an outstanding conformational change of the loop between Pro124 and Ala133, with which the side chains of Arg152 formed multiple hydrogen bonds in the wild-type, but not His152 in the mutant

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Nevertheless, the anticoagulant activity of LH NP and TLH NP, expressed as the content of LMWH, was almost comparable to that of LMWH, indicating that nanotherapies did not compromise the LMWH activity

Here, three derivatives of quercetin were synthesised, namely quercetin 3-O--D-glucoside, quercetin 3-O--D-lactoside, 3 sialyllactosyl quercetin and 6 sialyllactosyl quercetin