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Although some progress has been made in the study of flavonoids in iron overload, research has mainly focused on in vitro studies and l sufficient in vivo and clinical evidence is lacking, which are important considerations in evidence-based medicine

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18, 20 A key difference between our results and other studies is the use of a lethal small molecule (named CETZOLE) that may act as both a system x c - inhibitor and a covalent inhibitor of GPX4 and other proteins

Patil et al., 2019), which may be correlated with the LOX family members

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