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We collected the sequences of the 3,871,657 gene non-redundant gene catalogue from the 396 human gut microbiome samples ( 15

DOI: 10.1016/j.pharmthera.2017.10.010

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Energy deficiency can stimulate the proliferation of mitochondria of smooth muscle and small vascular endothelial cells and cause angiopathy (such as MELAS syndrome), resulting in damage to microvascular hemoperfusion and insufficient energy supply to the brain (16)