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A case in point, when 2 different mouse strains were exposed to therapeutic or hepatotoxic doses of APAP, depletion of GSH or APAP protein adduct formation was only detected in the liver but not in the whole brain or individual brain regions, suggesting that there is no evidence for the formation of the reactive metabolite NAPQI in the brain of adult mice [185]

External harmful agents, like radiation, smoking, toxins, and alcohol, can also stimulate ROS production [45,55]

Domain Target: Collagen expression Extracellular matrix organization PubMed Research COMPOUND 04 / 04 Inflammatory Domain KPV Inflammatory Response

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Diabetes Care 22:623634