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Before operations for advanced keratoconus, patients are intolerant to wearing contact lens for long periods because the curvature of the cornea is excessively steep and thus contact lenses do not properly sit on the corneal surface, leading to lens movement, refractive irregularities and discomfort or irritation in the eye

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doi: 10.1128/iai.62.9.3663-3671.1994 Seiler KP, Vavrin Z, Eichwald E, et al

Efficacy and safety of mecapegfilgrastim for prophylaxis of chemotherapy-induced neutropenia in patients with breast cancer: a randomized, multicenter, active-controlled phase III trial