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Vancouver, BC, Canada, November 15, 1997

Analysis of the promoter regions of SLC7A11 and SLC3A2 utilizing the online resource JASPAR ( revealed the presence of potential estrogen response element (EREs), resembling the ER binding motif, situated within the 1.5 kb promoter regions upstream of the transcription start sites of SLC7A11 and SLC3A2 (Fig

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Upon encountering an unfavorable stimulus, unfolded or incorrectly folded proteins have the ability to activate the unfolded protein response (UPR) signaling pathway, which then transports them out of the ER where they are degraded by the proteasome (173, 174)

Nat Commun 10(1):3143 Oh G, Wang A, Wang L et al (2023) POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling