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The authors concluded that larazotide acetate reduced IEB permeability assessed by lactulose/mannitol permeability test, proinflammatory cytokine production, and gastrointestinal symptoms in CD after gluten exposure (279)

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When administered as a 250 mg rectal suppository, glutathione bypasses the gastrointestinal tract, potentially reducing degradation by stomach acids and enzymes, thus allowing for better absorption

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All patients were recruited to the Latvian National biobankGenome Database of the Latvian population [27]

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