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At concentrations of 1 pM1 nM, DSIP stimulated calcium-dependent release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro suggesting any antinociceptive effects observed in animal models may be mediated through endogenous opioid peptide release rather than direct receptor binding [7]

doi: 77

Haloperidol serum levels were obtained about 2 months after administration of the second dose of haloperidol decanoate, which resulted 1 ng/mL (subtherapeutic)

However, in the case of delivery of anti-cancer agents via L-lysine-methotrexate conjugate as well as paclitaxel and docetaxel nanocarrier formulations, the extent of drug delivery into tumors would be a more relevant parameter to investigate than K p,brain

(2024) 68(3):e2300522