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Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

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184 NAD + manipulates the gene expression Cellular metabolism, such as NAD + metabolism, is directly connected to gene expression through regulating the post-translational modifications (PTMs) of histones, the covalent chemical modifications of DNA, the activity of transcription factor and RNA processing

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Electrochemotherapy (ECT) synergistically combines PEFs with chemotherapeutic agents: drugs are administered intratumorally before PEFs application, where transient membrane permeabilization enhances intracellular drug uptake, significantly potentiating cytotoxicity against treatment-resistant malignancies

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10.3390/ijms19092770 16 KiG

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Shuying (Sheri) Yang is an associate professor in the Department of Basic & Translational Sciences in the University of Pennsylvania School of Dental Medicine

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