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Opening a chloride channel will allow the negatively charged chloride ion to enter the cell and will reduce the electrical charge inside the cell (thereby hyperpolarizing it) and effectively render the neuron unresponsive to incoming stimuli that would otherwise depolarize the cell

The PI3K/Akt/mTOR pathway plays a crucial role in regulating autophagy in human cancers and serves as a vital detector of nutrient and growth factor rates [278, 279]

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After incubation with cells overnight, the culture medium was removed and washed with PBS three times

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To identify biomarkers of immune aging, KIAMO allows to query proteins, for example, with increased abundance in older plasma and head kidney tissues, and to correlate these findings with scRNA-seq data from the same tissues