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GRX1-/- mice exhibit attenuated LPS-induced cytokine release (IL-1 and TNF-) and macrophage dysfunction, suggesting the dual role of GRX1 in the regulation of inflammation (90)

In contrast to these findings, skeletal muscle-specific TSC1-deficient mice (TSCmKO), which show sustained activation of mTORC1, developed a late-onset myopathy related to impaired autophagy [62]

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Subsequent cell- and animal- based assays confirmed that Al 2 O 3 NPs caused mitochondria-dependent apoptosis and oxidative stress either in vitro or in vivo, which were consistent with the trends of gene regulation

DIRECTIONS FOR USE Use strictly according to the manufacturers directions

Required Documentation Elements All three components must work together