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and decreased mRNA expression of proinflammatory cytokines IL-1, IL-6, and TNF, suppressed NF-B activation, and inhibited the stressed-induced NLRP3 inflammasome axis activation, along with reducing the transformation of pro-IL-1 into mature IL-1

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Urate can be oxidized by one-electron transfer to a urate radical anion, which can then be recycled in the presence of ascorbate (Figure 3)

Except for the Sham group, which received intraperitoneal injections of physiological saline, the remaining five groups were administered daily intraperitoneal injections of 5 mg/kg testosterone propionate