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Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis

E., Sudderth, J., Yue, Y., Zia, A., Glass, D., Deberardinis, R

Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancer

National Academies of Sciences, Engineering, and Medicine

The apparent Michaelis-Mentes constant (K m ), maximum velocity for the enzyme preparation (V max ) and specific activity of the enzyme fraction obtained from the plot were 6.83 M, 0.46 nmoles ml reaction mixture-1 min -1 and 0.34 nmoles g protein -1 min -1

For all experiments, APR-246 was administered at 100 mg kg 1 daily and SAS at 6 mg per mouse twice daily