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doi: 10.20517/cdr.2021.138 12 NicholsonHASawersLClarkeRGHiomKJFergusonMJSmithG

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Cytosolic mtDNA then acts as a persistent trigger of innate immune pathways (e.g., cGAS-STING, NLRP3), fueling chronic inflammation that drives accelerated aging and non-AIDS comorbidities despite virological suppression