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The C-terminal amidation (NH) and strategic amino acid substitutions within the sequence contribute to its reported receptor binding selectivity and proteolytic stabilityproperties that are relevant for designing controlled in vitro assay conditions

Studies show that this co-administration produces a significantly greater increase in GH than either peptide administered alonea synergistic, not merely additive, effect

10.1016/j.tree.2020.10.015 112 Ruiz-AlonsoM.BlesaD.Diaz-GimenoP.GomezE.Fernandez-SanchezM.CarranzaF.et al (2013)

Although astrocyte dysfunction and iron dysregulation are increasingly recognized in AD pathology, their direct causal link to disease progressionand particularly to hypothesized central mechanisms such as ferroptosisrequires further validation in human contexts

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